Back to Previous Page

Kidney Cancer

(Renal Cell Carcinoma)

Definition

Kidney cancer is a disease in which cancer cells grow in the kidneys. The kidneys are two bean-shaped organs, located just above the waist, on each side of the spine. Their main function is to filter the blood and produce urine by which the body rids itself of waste products and excess water.
Cancer occurs when cells in the body (in this case kidney cells) divide without control or order. Normally, cells divide in a regulated manner. If cells keep dividing uncontrollably when new cells are not needed, a mass of tissue forms, called a growth or tumor. The term cancer refers to malignant tumors, which can invade nearby tissue and spread to other parts of the body. A benign tumor does not invade or spread.
There are two main types of kidney cancer: Wilms tumor, which occurs predominantly in children, and renal cell carcinoma in adults. The cells that line the ureter may also give rise to transitional cell cancer, and the connective tissues of the kidney may produce sarcomas, which are rare.
Cancer Cell Growth
IMAGE
Copyright © Nucleus Medical Media, Inc.

Causes

The cause of kidney cancer is unknown.

Risk Factors

A risk factor is something that increases your chance of getting a disease or condition.
Risk factors for kidney cancer include:
  • Smoking
  • Family history of certain hereditary forms of kidney cancer
  • Age: 50 years or older
  • Sex: male
  • Certain occupational exposures (like asbestos and aniline) and tanning products
  • Exposure to some toxins, such as astrolachia (an herb common in some Chinese herbal preparations)
  • Balkan nephritis
  • Chronic renal stones
  • Phenacetin abuse
  • Tuberous sclerosis—a hereditary condition that causes tumors to grow in many different organs, including angiomyolipomas of the kidney, a benign tumor
  • Dialysis treatment
  • Von Hippel Lindau syndrome—a syndrome associated with many types of cancer

Symptoms

Symptoms may include:
  • Blood in the urine
  • Unexplained lower back pain or new pain elsewhere
  • Shortness of breath or cough
  • Lump in the belly
  • Elevated blood pressure
  • Unplanned, significant weight loss
  • Unexplained fever
  • Swelling of ankles, legs, and/or abdomen

Diagnosis

Your doctor will ask about your symptoms and medical history, and perform a physical exam.
Tests may include:
  • Blood and urine tests—to check kidney function or find substances that indicate kidney cancer may be present
  • Bone scan—for this test, you receive a special radioactive material that specifically lights up bones that are undergoing an active process, such as tumor growth. Kidney cancer likes to spread to the bones. This test is often performed to ensure the bones are not involved by the cancer.
  • Chest x-rays and abdomen x-rays—tests that use radiation to take pictures of structures inside the body
  • IV pyelogram—an x-ray of the kidneys and ureters after injection of contrast dye into the blood
  • Renal angiography—an x-ray of arteries that are leading to a possible kidney tumor
  • CT scan—a type of x-ray that uses a computer to make pictures of the inside of the kidneys and the surrounding area
  • MRI scan—a test that uses magnetic waves to make pictures of the inside of the kidneys and the surrounding area
  • Renal ultrasound—a test that uses sound waves to examine the kidneys
  • Laparoscopy—a thin, lighted tube inserted through a small incision in the abdomen to look at the kidney
  • Cytoscopy—examination of the bladder, ureters, and kidneys via a thin tube inserted through the urethra
  • Biopsy—removal of a sample of kidney tissue to test for cancer cells

Treatment

Once kidney cancer is found, staging tests are performed. The purpose of these tests is to find out if the cancer has spread and, if so, to what extent. Treatment depends on the stage.
Surgery is the most important component of any curative approach to kidney cancer. There is some information suggesting immunotherapies (interleukin or interferon) may be of some benefit. Radiation can be used to treat kidney cancer that has spread to the lung, bones, or brain, but it is not considered curative.

Surgery

This involves the removal of a cancerous tumor, nearby tissue, and possibly nearby lymph nodes. Surgeries to treat kidney cancer include:
  • Radical nephrectomy—removal of the entire kidney, adrenal gland, and nearby fatty tissue and lymph nodes
  • Partial nephrectomy—removal of the cancerous part of the kidney only, used to treat smaller tumors that have not spread locally.
  • Removal of metastases—removal of cancerous tissue that has spread to other parts of the body, particularly when causing symptoms

Radiation Therapy (or Radiotherapy)

This is the use of radiation to kill cancer cells and shrink tumors. Radiation may be:
  • External radiation therapy—radiation directed at the tumor from a source outside the body

Chemotherapy

This is the use of drugs to kill cancer cells. Chemotherapy may be given in many forms including pill, injection, and via a catheter. The drugs enter the bloodstream and travel through the body killing mostly cancer cells but also some healthy cells.

Immunotherapy

This procedure involves the use of drugs like interleukin-2 and interferon alpha to help the immune system fight and destroy cancer cells.

Targeted Therapy

Targeted therapy includes using drugs called tyrosine kinase inhibitors. Examples include sunitinib (Sutent) and sorafenib (Nexavar). These medicines have been shown to increase the survival rate in people with kidney cancer. Another class of drugs called mammalian target of rapamycin (mTOR) inhibitors may also help people with kidney cancer live longer. Temsirolimus (Torisol) is an example of this type of drug.

Medication

These medicines may be prescribed to adults with advanced kidney cancer:
  • Everolimus (Zortress)
  • Pazopanib (Votrient)

Prevention

Measures to prevent kidney cancer are limited:
  • Avoid using tobacco products.
  • Avoid occupational exposures.
See your doctor at the first sign of possible symptoms, since early detection is the key to cure.

RESOURCES

American Cancer Society http://www.cancer.org

The Kidney Cancer Association http://www.kidneycancer.org

CANADIAN RESOURCES

Canadian Cancer Society http://www.cancer.ca

The Kidney Foundation of Canada http://www.kidney.ca

References

All about kidney cancer. American Cancer Society website. Available at: http://www.cancer.org/cancer/kidneycancer/index. Accessed July 1, 2009.

Berkow R, Beers MH. The Merck Manual of Medical Information. New York, NY: Simon and Schuster; 2000.

Cashen A, Wildes T. The Washington Manual: Hematology and Oncology Subspeciality Consult. 2nd ed. Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2008.

Kidney (renal cell) cancer. National Cancer Institute website. Available at: http://www.cancer.gov/cancertopics/types/kidney. Accessed July 1, 2009.

Renal cell carcinoma. EBSCO DynaMed website. Available at: https://dynamed.ebscohost.com/about/about-us. Updated July 14, 2010. Accessed July 15, 2010.

Revision Information

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

Copyright © EBSCO Publishing
All rights reserved.